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Rab18 Drift in Lipid Droplet and Endoplasmic Reticulum Interactions of Adipocytes under Obesogenic Conditions.
López-Alcalá J, Soler-Vázquez MC, Tercero-Alcázar C, Sánchez-Ceinos J, Guzmán-Ruiz R, Malagón MM, Gordon A. López-Alcalá J, et al. Int J Mol Sci. 2023 Dec 6;24(24):17177. doi: 10.3390/ijms242417177. Int J Mol Sci. 2023. PMID: 38139006 Free PMC article.
Our results show that adipocytes differentiated in fibrotic conditions caused ER fragmentation, the expansion of ER-LD contact sites, and modified Rab18 dynamics. Likewise, adipocytes exposed to inflammatory conditions favored ER-LD contact, Rab18 accumulation in th …
Our results show that adipocytes differentiated in fibrotic conditions caused ER fragmentation, the expansion of ER-LD contact sites, and mo …
Cloning and characterization of a novel splice variant of human Rab18 gene (RAB18).
Dou T, Ji C, Gu S, Chen F, Xu J, Ye X, Ying K, Xie Y, Mao Y. Dou T, et al. DNA Seq. 2005 Jun;16(3):230-4. doi: 10.1080/10425170500061681. DNA Seq. 2005. PMID: 16147880
Research indicates RAB18 may relate to inflammation and some kinds of tumor. Here we report a splice variant of RAB18, which is 2571 bp in length and has an open reading frame coding a predicted 235 amino-acids protein. RT-PCR shows that the cDNA has differen …
Research indicates RAB18 may relate to inflammation and some kinds of tumor. Here we report a splice variant of RAB18, …
Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders.
Liu J, Li L, Xu D, Li Y, Chen T, Liu Y, Bao Y, Wang Y, Yang L, Li P, Xu L. Liu J, et al. Sci China Life Sci. 2024 Mar 22. doi: 10.1007/s11427-023-2367-9. Online ahead of print. Sci China Life Sci. 2024. PMID: 38523235
When subjected to high-fat diet (HFD), Rab18 AKO mice had increased ER stress and inflammation, reduced adiponectin, and decreased triacylglycerol (TAG) accumulation in SAT. ...Rab18 AKO mice developed insulin resistance and systematic inflammation. .. …
When subjected to high-fat diet (HFD), Rab18 AKO mice had increased ER stress and inflammation, reduced adiponectin, and decre …
Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine.
Schäfer U, Seibold S, Schneider A, Neugebauer E. Schäfer U, et al. FEBS Lett. 2000 Jan 21;466(1):148-54. doi: 10.1016/s0014-5793(99)01778-0. FEBS Lett. 2000. PMID: 10648831 Free article.
Here we report the isolation of a cDNA encoding the complete human rab18 protein from histamine-stimulated endothelial cells using differential display. ...This finding might also imply a role for rab proteins in inflammation....
Here we report the isolation of a cDNA encoding the complete human rab18 protein from histamine-stimulated endothelial cells using di …
Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds.
Kulkarni M, O'Loughlin A, Vazquez R, Mashayekhi K, Rooney P, Greiser U, O'Toole E, O'Brien T, Malagon MM, Pandit A. Kulkarni M, et al. Biomaterials. 2014 Feb;35(6):2001-10. doi: 10.1016/j.biomaterials.2013.11.003. Epub 2013 Dec 10. Biomaterials. 2014. PMID: 24331702
In the hyper-secretory wound microenvironment of hyperglycemia, Rab18, a secretory control molecule, was found to be significantly downregulated. Using a biomaterial platform for dual therapy targeting the two distinct pathways, this study aimed to resolve the major dysreg …
In the hyper-secretory wound microenvironment of hyperglycemia, Rab18, a secretory control molecule, was found to be significantly do …